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29 Aug 08:32

One-Step Electrodeposited Nickel Cobalt Sulfide Nanosheet Arrays for High-Performance Asymmetric Supercapacitors

by Wei Chen, Chuan Xia and Husam N. Alshareef

TOC Graphic

ACS Nano
DOI: 10.1021/nn503814y
04 Aug 14:23

A Boronate Affinity Sandwich Assay: An Appealing Alternative to Immunoassays for the Determination of Glycoproteins

by Jin Ye, Yang Chen, Zhen Liu

Abstract

Immunoassay has been an essential tool in many areas, including clinical diagnostics. However, it suffers from drawbacks, such as poor availability of high specificity antibodies, limited stability of biological reagents, as well as damage to health and susceptibility of chemical labels to the sample environment. Here we present a new approach, a boronate-affinity sandwich assay (BASA), for the specific and sensitive determination of trace glycoproteins in complex samples. BASA relies on the formation of sandwiches between boronate-affinity molecularly imprinted polymers (MIPs), target glycoproteins, and boronate-affinity surface-enhanced Raman scattering (SERS) probes. The MIP ensures the specificity, while the SERS detection provides the sensitivity. BASA overcomes the drawbacks of traditional immunoassays and offers a great prospect for application.

Thumbnail image of graphical abstract

A specific and sensitive approach has been developed to detect trace levels of glycoproteins in complex samples. A target glycoprotein is specifically captured by a boronate-affinity molecular-imprinted polymer array and then labeled with boronate-affinity silver nanoparticles. The surface-enhanced Raman scattering of the resulting complex (see picture) is then measured.

05 Jun 06:00

Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer

by Jong-Min Lim, Archana Swami, Laura M. Gilson, Sunandini Chopra, Sungyoung Choi, Jun Wu, Robert Langer, Rohit Karnik and Omid C. Farokhzad

TOC Graphic

ACS Nano
DOI: 10.1021/nn501371n