27 Jul 00:00

Synthesis of hydroxyphthioceranic acid using a traceless lithiation–borylation–protodeboronation strategy

by Ramesh Rasappan

Nature Chemistry. doi:10.1038/nchem.2010

Authors: Ramesh Rasappan & Varinder K. Aggarwal

Coupling of carbamates with boronic esters followed by protodeboronation creates a new carbon–carbon bond, leaving behind no trace of the functional groups used to create it. Now, methodology for the protodeboronation of alkyl pinacol boronic esters has been developed and an iterative lithiation–borylation–protodeboronation strategy used in a 14-step stereocontrolled synthesis of hydroxyphthioceranic acid.

26 Jul 19:00

​Sell Someone on Your Idea by Taking Them Out to Lunch

by Dave Greenbaum

​Sell Someone on Your Idea by Taking Them Out to Lunch

You might think that paying for lunch is a cheap bribe, but lunch can be a smart way to control the situation and present your ideas in the best possible way.

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26 Jul 18:26

This. Is. Spartaaaaa! [x]





This. Is. Spartaaaaa! [x]

26 Jul 17:48

Side Eyeing Chloe | f5d.jpg

f5d.jpg
26 Jul 16:50

roadsworth

by seanf
26 Jul 15:37

Atheism | 0cd.png

0cd.png
26 Jul 14:58

The Avengers | 50e.jpg

50e.jpg
26 Jul 14:49

Harry Potter | cf9.png

cf9.png
26 Jul 14:24

Private Data On iOS Devices Not So Private After All

by timothy
theshowmecanuck (703852) writes with this excerpt from Reuters summarizing the upshot of a talk that Jonathan Zdziarski gave at last weekend's HOPE conference: Personal data including text messages, contact lists and photos can be extracted from iPhones through previously unpublicized techniques by Apple Inc employees, the company acknowledged this week. The same techniques to circumvent backup encryption could be used by law enforcement or others with access to the 'trusted' computers to which the devices have been connected, according to the security expert who prompted Apple's admission. Users are not notified that the services are running and cannot disable them, Zdziarski said. There is no way for iPhone users to know what computers have previously been granted trusted status via the backup process or block future connections. If you'd rather watch and listen, Zdziarski has posted a video showing how it's done.

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26 Jul 13:30

Recommended Reading: 'Lucy's' bad science and space movie inaccuracies

by Billy Steele
Recommended Reading highlights the best long-form writing on technology and more in print and on the web. Some weeks, you'll also find short reviews of books that we think are worth your time. We hope you enjoy the read. Lucy's Based on Bad...
26 Jul 13:13

How North Korea got this way

Vox's Max Fisher explains the historical events that produced the bizarre, tragic North Korea we know today.
26 Jul 12:44

The true meaning of words

26 Jul 12:29

Enraged Verizon FiOS Customer Seemingly Demonstrates Netflix Throttling

by timothy
MojoKid (1002251) writes The ongoing battle between Netflix and ISPs that can't seem to handle the streaming video service's traffic, boiled over to an infuriating level for Colin Nederkoon, a startup CEO who resides in New York City. Rather than accept excuses and finger pointing from either side, Nederkoon did a little investigating into why he was receiving such slow Netflix streams on his Verizon FiOS connection. What he discovered is that there appears to be a clear culprit. Nederkoon pays for Internet service that promises 75Mbps downstream and 35Mbps upstream through his FiOS connection. However, his Netflix video streams were limping along at just 375kbps (0.375mbps), equivalent to 0.5 percent of the speed he's paying for. On a hunch, he decided to connect to a VPN service, which in theory should actually make things slower since it's adding extra hops. Speeds didn't get slower, they got much faster. After connecting to VyprVPN, his Netflix connection suddenly jumped to 3000kbps, the fastest the streaming service allows and around 10 times faster than when connecting directly with Verizon. Verizon may have a different explanation as to why Nederkoon's Netflix streams suddenly sped up, but in the meantime, it would appear that throttling shenanigans are taking place. It seems that by using a VPN, Verizon simply doesn't know which packets to throttle, hence the gross disparity in speed.

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26 Jul 11:37

Tumbling towards ecstasy...

by antbaena
26 Jul 11:00

Poor Drunken Barney

Poor Drunken Barney

Submitted by: (via Ohio's Finest)

Tagged: booze , drunk , barney , funny , after 12
26 Jul 07:41

ثوابش مال شما، گناهش مال من!

by nikolaa

 وقتی بچه بودم و بابا دستم را می گرفت و تا سر کوچه همراهم می آمد که سوار سرویسم کند، مدام از این طرف به آن طرف می پریدم و همانطور که دست های بابا را دنبال خودم می کشاندم پاهام را تنگ و گشاد و باز و بسته می کردم و کج و کوله راه می رفتم که فقط ته کتانی های سفید خوشگلم به تف هایی که مردم کف کوچه انداخته اند نخورد.

هنوز هم همینم. وقتی از خانه می زنم بیرون به جای اینکه روبرویم را نگاه کنم فقط باید حواسم را جمع کنم که روی تف های کف خیابان راه نروم. دیگر ملودی "ااااخ ، توووووف" آدم ها که از 5 صبح تا نصفه شب توی کوچه نواخته می شود را حفظ شده ام. مخصوصا توی ماه رمضان که ملودی سرعت بیشتری می گیرد و آدم ها برای اینکه آب دهان و خلط های توی گلویشان را قورت ندهند و روزه شان باطل نشود، آن را در هر جای ممکن از باغچه ای که تازه توی آن شمعدانی کاشته شده تا خیابان و جلوی در خانه ها، تف می کنند.

آن وقت چه می شود؟ من نوعی باید وقت راه رفتن هی فاصله پاهایم را کم و زیاد کنم و حواسم به تف ها و خلط ها باشد و هم زمان به این فکر کنم که روزه مگر فقط حق الله است؟ این تف ها که حال مردم را بهم می زنند بی شک فرو خوردنشان از کف خیابان انداختنشان روا تر است. کاش می شد یک تابلو بزنیم جلوی خانه هایمان که "جان هر کس دوست دارید، تف هایتان را بخورید لطفا! "

+ یادبان را هم یادتان نرود ببینید.

26 Jul 04:12

Цитата #429278

2 часа смотрел смотрел передачу про террористов, на рекламе переключил на какую то передачу про охоту и уперся на кухню. Слышу оттуда:
"...побег из ямы, который кабан устроил, взрыв стенки своим рылом..."
Минут пять пытался врубиться, как кабан умудрился устроить ВЗРЫВ какой-то там стенки своим рылом о_O
26 Jul 02:40

Clever crow knows exactly how to solve different puzzles to get food

by Casey Chan on Sploid, shared by Casey Chan to Gizmodo

Clever crow knows exactly how to solve different puzzles to get food

I love it when animals can solve puzzles and problems that I can't even figure out. Here's a crow going through a bunch of different exercises to show its understanding of size, weight, density, the elements and even the amount of effort it should put in to a puzzle to win its reward.

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26 Jul 02:03

Two days in a car and my Grand Uncle, Grand Aunt, cousin and...



















Two days in a car and my Grand Uncle, Grand Aunt, cousin and myself made it to Cape Breton.

25 Jul 22:45

5 librerías JavaScript para crear diagramas y gráficos sin mucho esfuerzo

by Andrea Rodriguez
data-visualization

Modela la data de tus sitios de la mejor manera con estas 5 librerías JavaScript para gráficos y diagramas con las que puedes lograr hermosos resultados.

Resulta que eres un desarrollador web y estás buscando la mejor manera de mostrar la data de tus proyectos en tus sitios. La respuesta es sencilla, con JavaScript. Si ya lo estabas usando seguro coincidirás conmigo en que con algunas de sus librerías se pueden lograr resultados maravillosos; de lo contrario te recomiendo darle un vistazo a estás 5 librerías para visualizar datos, crear diagramas y gráficos.

Highcharts

highcharts

Highcharts es una librería escrita en JavaScript que permite construir gráficos interactivos para tus proyectos web. Tiene una gran cantidad de demos que se pueden ver y editar en JSFiddle. Tiene algunas características de gran alcance y está basada en tecnologías de navegación nativas, no necesita plugins y es compatible con todos los navegadores modernos incluyendo sus versiones móviles y el viejo Internet Explorer 6. Es de uso libre para organizaciones no comerciales, para el resto de sus clientes ofrecen varios planes. Highcharts en una librería Open Source, puedes ver su código fuente en GitHub. También unirte a sus comunidades en Facebook y Twitter.

Charts.js

chartsjs

Charts.js es una librería con la que puedes crear gráficos simples, limpios y atractivos, es usada tanto por diseñadores y desarrolladores. Entre sus características podemos mencionar que posee 6 tipos de gráficos no tiene dependencias y es super ligero. Utiliza el elemento canvas de HTML5 y está disponible en todos los navegadores modernos, incluso brinda soporte a Internet Explorer 7 y 8. Chart,js tiene diseño adaptativo, es modular e interactivo. Para más información puedes revisar la documentación completa en su sitio. Es un proyecto Open Source, puedes ver su código fuente en su repositorio de GitHub.

Google Charts Tools

Google Charts Tools es una herramienta libre, fácil de usar y tiene de todo un poco, desde gráficos de líneas simples hasta los mapas de árboles jerárquicos complejos. Su galería proporciona un gran número de tipos de gráficos bien diseñados. Puedes usarlos a través de un sencillo JavaScript que se incrusta en tu sitio. Basta con cargar algunas bibliotecas de gráficos de Google, listar los datos a ser mostrados, seleccionar las opciones de personalización para crear un objeto gráfico con un identificador que tu mismo seleccionas. Puedes visitar su guía de inicio rápido para más información o unirte a su comunidad de desarrolladores en Google +.

Fusion Charts

fusion-charts

Fusion Charts es una librería JavaScript para crear gráficos muy popular, cuentan con más de 22.000 clientes y 500.000 usuarios en 118 países. Tienen 90 tipos de gráficos que funcionan a través de varios dispositivos y todos los navegadores modernos, incluyendo Internet Explorer 6, 7 y 8 utilizando VML. Entre otras bondades, poseen amplia documentación, ejemplos de varios tipos listos para explorar y un plugin jQuery listo para usar. Es de uso libre para organizaciones no comerciales, para el resto de sus clientes ofrecen una versión de prueba así como varios planes. Puedes encontrar más información de Fusion Charts en su blog; también puedes unirte a sus comunidades de Facebook, Twitter y Google +.

Epoch

epoch

Epoch es una librería de gráficos en tiempo real de uso general para la construcción de bellas visualizaciones de gran funcionamiento. Se centra en dos aspectos diferentes de la visualización: gráficos básicos para la creación de informes históricos y gráficos en tiempo real para la visualización de la frecuencia de actualización de datos en series de tiempo. Para los conjuntos de datos grandes y estáticos, ofrecen un conjunto de graficos como de área, barras agrupadas, líneas, circulares y de dispersión. Para la supervisión en tiempo real, usan gráficos basados ​​en Canvas HTML5 como area, barras, manómetro, mapa de calor y de líneas. Recomiendo revisar su guía rápida para tener una idea de como comenzar. Epoch es un proyecto Open Source, puedes ver su código fuente visitando su repositorio en GitHub.








25 Jul 22:00

asylum-art: Forest Rogers Sculptures facebook,  deviantART  ...

25 Jul 21:38

Microsoft unleashes 'Settlers of Catan' on the web

by Dana Wollman
Microsoft has something of an extracurricular activity: When it's not releasing Office for iPad or updating Windows, it has a habit of helping other companies build websites. Its latest project is a web version of Settlers of Catan, the popular board...
25 Jul 21:30

Become a Better Listener by Following These Five Rules

by Thorin Klosowski

Become a Better Listener by Following These Five Rules

Being a good speaker is easy, but being a good listener is a lot harder. If you're trying to work on your listening skills, The Wall Street Journal outlines a few simple tips to help you tune in.

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25 Jul 20:47

Es algo digno de probar - Puede convertir la cámara de tu móvil en una poderosa lupa


25 Jul 19:40

Insights into the Asymmetric Heterogeneous Catalysis in Porous Organic Polymers: Constructing A TADDOL-Embedded Chiral Catalyst for Studying the Structure–Activity Relationship[ ]

by Wan-Kai An, Man-Yi Han, Chang-An Wang, Si-Min Yu, Yuan Zhang, Shi Bai, Wei Wang

Abstract

Construction of porous organic polymers (POPs) as asymmetric catalysts remains as an important but challenging task. Herein, we exploit the “bottom-up” strategy to facilely synthesize an α,α,α′,α′-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL)-based chiral porous polymer (TADDOL-CPP) for highly efficient asymmetric catalysis. Constructed through the covalent linkages among the three-dimensional rigid monomers, TADDOL-CPP possesses hierarchical porous structure, high Brunauer–Emmett–Teller (BET) surface area, together with abundant and uniformly-distributed chiral sites. In the presence of [Ti(OiPr)4], TADDOL-CPP acts as a highly efficient and recyclable catalyst in the asymmetric addition of diethylzinc (Et2Zn) to aromatic aldehydes. Based on the direct observation of the key intermediates, the reaction mechanism has been revealed by solid-state 13C magic-angle spinning (MAS) NMR spectroscopy. In combination with the catalytic testing results, characterization on the working catalyst provides further information for understanding the structure–activity relationship. We suggest that the catalytic activity of TADDOL-CPP is largely affected by the structural rigidity, cooperative catalysis, local chiral environment, and hierarchical porous framework. We expect that the information obtained herein will benefit to the designed synthesis of robust POP catalysts toward practical applications.

Thumbnail image of graphical abstract

POP performance: Construction of porous organic polymers (POPs) as asymmetric catalysts remains as an important but challenging task. A tetraaryl-1,3-dioxolane-4,5-dimethanol-embedded chiral porous polymer (TADDOL-CPP) was facilely constructed—it exhibited excellent activity and reusability in the asymmetric addition of Et2Zn to aromatic aldehydes (see figure). The catalytic performance of TADDOL-CPP is affected by the rigidity of the monomers, the cooperative catalysis, the local chiral environment, and the hierarchical porous structure. A detailed reaction mechanism is also proposed.